N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)
Homo sapiens — UniProt Q8N0V5
Data last refreshed: (UniProt release unknown)
Key facts
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) is a protein from Homo sapiens identified by UniProt accession Q8N0V5, 402 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8N0V5; gene symbol GCNT2.
- Organism: Homo sapiens.
- Length: 402 amino acids.
- Top disease associations (Open Targets): cataract 13 with adult I phenotype, Total congenital cataract and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase |
|---|---|
| UniProt accession | Q8N0V5 |
| Gene | GCNT2 |
| Organism | Homo sapiens |
| Length | 402 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- cataract 13 with adult I phenotype · score 0.72
- Total congenital cataract · score 0.55
- monocyte count · score 0.48
- lymphocyte count · score 0.46
- monocyte percentage of leukocytes · score 0.42
- urate measurement · score 0.40
- leukocyte count · score 0.40
- Developmental cataract · score 0.40
- early-onset non-syndromic cataract · score 0.40
- myeloid white cell count · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0V5-F1 | alphafold | PREDICTED | 91.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0V5.
Amino-acid sequence (402 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GCNT2?
The strongest Open Targets associations for GCNT2 are cataract 13 with adult I phenotype, Total congenital cataract, monocyte count, lymphocyte count and monocyte percentage of leukocytes.
How long is the GCNT2 protein?
The Homo sapiens GCNT2 protein (UniProt Q8N0V5) is 402 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0V5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0V5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.