L-fucose kinase (FCSK)
Homo sapiens — UniProt Q8N0W3
Data last refreshed: (UniProt release unknown)
Key facts
L-fucose kinase (FCSK) is a protein from Homo sapiens identified by UniProt accession Q8N0W3, 1084 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8N0W3; gene symbol FCSK.
- Organism: Homo sapiens.
- Length: 1084 amino acids.
- Target class: Kinase.
- Top disease associations (Open Targets): congenital disorder of glycosylation with defective fucosylation, congenital disorder of glycosylation and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | L-fucose kinase |
|---|---|
| UniProt accession | Q8N0W3 |
| Gene | FCSK |
| Organism | Homo sapiens |
| Length | 1084 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Kinase (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- congenital disorder of glycosylation with defective fucosylation · score 0.48
- congenital disorder of glycosylation · score 0.37
- diastolic blood pressure · score 0.24
- pulse pressure measurement · score 0.24
- serum alanine aminotransferase measurement · score 0.19
- Neurodevelopmental disorder · score 0.15
- mean arterial pressure · score 0.12
- body mass index · score 0.11
- systolic blood pressure · score 0.10
- apolipoprotein B measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0W3-F1 | alphafold | PREDICTED | 92.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0W3.
Amino-acid sequence (1084 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FCSK?
The strongest Open Targets associations for FCSK are congenital disorder of glycosylation with defective fucosylation, congenital disorder of glycosylation, diastolic blood pressure, pulse pressure measurement and serum alanine aminotransferase measurement.
How long is the FCSK protein?
The Homo sapiens FCSK protein (UniProt Q8N0W3) is 1084 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0W3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0W3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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