Neuroligin-4, X-linked (NLGN4X)
Homo sapiens — UniProt Q8N0W4
Data last refreshed: (UniProt release unknown)
Key facts
Neuroligin-4, X-linked (NLGN4X) is a protein from Homo sapiens identified by UniProt accession Q8N0W4, 816 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: Q8N0W4; gene symbol NLGN4X.
- Organism: Homo sapiens.
- Length: 816 amino acids.
- Top disease associations (Open Targets): autism, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuroligin-4, X-linked |
|---|---|
| UniProt accession | Q8N0W4 |
| Gene | NLGN4X |
| Organism | Homo sapiens |
| Length | 816 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- autism · score 0.59
- neurodegenerative disease · score 0.49
- genetic disorder · score 0.47
- X-linked intellectual disability · score 0.42
- X-linked complex neurodevelopmental disorder · score 0.37
- Crohn's disease · score 0.31
- vaginal discharge · score 0.30
- Asperger syndrome · score 0.16
- Intellectual disability · score 0.15
- autism spectrum disorder · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0W4-F1 | alphafold | PREDICTED | 79.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0W4.
Amino-acid sequence (816 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NLGN4X?
The strongest Open Targets associations for NLGN4X are autism, neurodegenerative disease, genetic disorder, X-linked intellectual disability and X-linked complex neurodevelopmental disorder.
How long is the NLGN4X protein?
The Homo sapiens NLGN4X protein (UniProt Q8N0W4) is 816 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0W4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0W4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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