Citramalyl-CoA lyase, mitochondrial (CLYBL)
Homo sapiens — UniProt Q8N0X4
Data last refreshed: (UniProt release unknown)
Key facts
Citramalyl-CoA lyase, mitochondrial (CLYBL) is a protein from Homo sapiens identified by UniProt accession Q8N0X4, 340 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.
- UniProt accession: Q8N0X4; gene symbol CLYBL.
- Organism: Homo sapiens.
- Length: 340 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, neurodegenerative disease and cortical thickness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Citramalyl-CoA lyase, mitochondrial |
|---|---|
| UniProt accession | Q8N0X4 |
| Gene | CLYBL |
| Organism | Homo sapiens |
| Length | 340 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (114)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.38
- neurodegenerative disease · score 0.31
- cortical thickness · score 0.27
- vitamin B12 measurement · score 0.24
- smoking status measurement · score 0.20
- smoking initiation · score 0.20
- sitting height measurement · score 0.16
- smoking behaviour measurement · score 0.15
- testosterone measurement · score 0.14
- smoking behavior · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0X4-F1 | alphafold | PREDICTED | 90.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0X4.
Amino-acid sequence (340 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLYBL?
The strongest Open Targets associations for CLYBL are heel bone mineral density, neurodegenerative disease, cortical thickness, vitamin B12 measurement and smoking status measurement.
How long is the CLYBL protein?
The Homo sapiens CLYBL protein (UniProt Q8N0X4) is 340 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0X4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0X4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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