Spartin (SPART)
Homo sapiens — UniProt Q8N0X7
Data last refreshed: (UniProt release unknown)
Key facts
Spartin (SPART) is a protein from Homo sapiens identified by UniProt accession Q8N0X7, 666 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q8N0X7; gene symbol SPART.
- Organism: Homo sapiens.
- Length: 666 amino acids.
- Top disease associations (Open Targets): Troyer syndrome, Neurodevelopmental delay and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spartin |
|---|---|
| UniProt accession | Q8N0X7 |
| Gene | SPART |
| Organism | Homo sapiens |
| Length | 666 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- Troyer syndrome · score 0.78
- Neurodevelopmental delay · score 0.45
- genetic disorder · score 0.41
- body height · score 0.31
- Global developmental delay · score 0.26
- Failure to thrive · score 0.26
- cerebellar ataxia · score 0.26
- Microcephaly · score 0.26
- Dysarthria · score 0.26
- Strabismus · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0X7-F1 | alphafold | PREDICTED | 62.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0X7.
Amino-acid sequence (666 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPART?
The strongest Open Targets associations for SPART are Troyer syndrome, Neurodevelopmental delay, genetic disorder, body height and Global developmental delay.
How long is the SPART protein?
The Homo sapiens SPART protein (UniProt Q8N0X7) is 666 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0X7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0X7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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