Probable phosphoglycerate mutase 4 (PGAM4)
Homo sapiens — UniProt Q8N0Y7
Data last refreshed: (UniProt release unknown)
Key facts
Probable phosphoglycerate mutase 4 (PGAM4) is a protein from Homo sapiens identified by UniProt accession Q8N0Y7, 254 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q8N0Y7; gene symbol PGAM4.
- Organism: Homo sapiens.
- Length: 254 amino acids.
- Top disease associations (Open Targets): Graves disease, cancer and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable phosphoglycerate mutase 4 |
|---|---|
| UniProt accession | Q8N0Y7 |
| Gene | PGAM4 |
| Organism | Homo sapiens |
| Length | 254 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- Graves disease · score 0.07
- cancer · score 0.02
- lung adenocarcinoma · score 0.01
- Infertility · score 0.01
- hepatocellular carcinoma · score 0.01
- Azoospermia · score 0.01
- Menkes disease · score 0.01
- neoplasm · score 0.00
- head and neck squamous cell carcinoma · score 0.00
- squamous cell lung carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0Y7-F1 | alphafold | PREDICTED | 94.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0Y7.
Amino-acid sequence (254 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PGAM4?
The strongest Open Targets associations for PGAM4 are Graves disease, cancer, lung adenocarcinoma, Infertility and hepatocellular carcinoma.
How long is the PGAM4 protein?
The Homo sapiens PGAM4 protein (UniProt Q8N0Y7) is 254 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0Y7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0Y7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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