Spindle and centriole-associated protein 1 (SPICE1)
Homo sapiens — UniProt Q8N0Z3
Data last refreshed: (UniProt release unknown)
Key facts
Spindle and centriole-associated protein 1 (SPICE1) is a protein from Homo sapiens identified by UniProt accession Q8N0Z3, 855 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q8N0Z3; gene symbol SPICE1.
- Organism: Homo sapiens.
- Length: 855 amino acids.
- Top disease associations (Open Targets): prostate carcinoma, cortical thickness and MODY.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spindle and centriole-associated protein 1 |
|---|---|
| UniProt accession | Q8N0Z3 |
| Gene | SPICE1 |
| Organism | Homo sapiens |
| Length | 855 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.10
- cortical thickness · score 0.06
- MODY · score 0.06
- colorectal cancer · score 0.06
- colorectal adenoma · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- IRIDA syndrome · score 0.05
- BMI-adjusted waist-hip ratio · score 0.05
- diabetes mellitus, permanent neonatal 4 · score 0.05
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0Z3-F1 | alphafold | PREDICTED | 56.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0Z3.
Amino-acid sequence (855 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPICE1?
The strongest Open Targets associations for SPICE1 are prostate carcinoma, cortical thickness, MODY, colorectal cancer and colorectal adenoma.
How long is the SPICE1 protein?
The Homo sapiens SPICE1 protein (UniProt Q8N0Z3) is 855 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0Z3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0Z3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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