Tetratricopeptide repeat protein 5 (TTC5)
Homo sapiens — UniProt Q8N0Z6
Data last refreshed: (UniProt release unknown)
Key facts
Tetratricopeptide repeat protein 5 (TTC5) is a protein from Homo sapiens identified by UniProt accession Q8N0Z6, 440 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q8N0Z6; gene symbol TTC5.
- Organism: Homo sapiens.
- Length: 440 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism, Global developmental delay and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tetratricopeptide repeat protein 5 |
|---|---|
| UniProt accession | Q8N0Z6 |
| Gene | TTC5 |
| Organism | Homo sapiens |
| Length | 440 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism · score 0.62
- Global developmental delay · score 0.46
- Intellectual disability · score 0.46
- microcephaly · score 0.46
- Hypotonia · score 0.46
- disease of genitourinary system · score 0.46
- Abnormality of the face · score 0.46
- Microcephaly · score 0.46
- Atypical behavior · score 0.46
- autosomal recessive non-syndromic intellectual disability · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0Z6-F1 | alphafold | PREDICTED | 93.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0Z6.
Amino-acid sequence (440 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTC5?
The strongest Open Targets associations for TTC5 are neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism, Global developmental delay, Intellectual disability, microcephaly and Hypotonia.
How long is the TTC5 protein?
The Homo sapiens TTC5 protein (UniProt Q8N0Z6) is 440 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0Z6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0Z6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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