tRNA pseudouridine synthase-like 1 (PUSL1)
Homo sapiens — UniProt Q8N0Z8
Data last refreshed: (UniProt release unknown)
Key facts
tRNA pseudouridine synthase-like 1 (PUSL1) is a protein from Homo sapiens identified by UniProt accession Q8N0Z8, 303 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q8N0Z8; gene symbol PUSL1.
- Organism: Homo sapiens.
- Length: 303 amino acids.
- Top disease associations (Open Targets): myxedema, inflammatory bowel disease and pulse pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA pseudouridine synthase-like 1 |
|---|---|
| UniProt accession | Q8N0Z8 |
| Gene | PUSL1 |
| Organism | Homo sapiens |
| Length | 303 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- myxedema · score 0.12
- inflammatory bowel disease · score 0.12
- pulse pressure measurement · score 0.09
- ulcerative colitis · score 0.06
- drug use measurement · score 0.06
- peak expiratory flow · score 0.04
- von Willebrand factor measurement · score 0.02
- reticulocyte count · score 0.02
- hepatocellular carcinoma · score 0.02
- prostate adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0Z8-F1 | alphafold | PREDICTED | 90.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0Z8.
Amino-acid sequence (303 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PUSL1?
The strongest Open Targets associations for PUSL1 are myxedema, inflammatory bowel disease, pulse pressure measurement, ulcerative colitis and drug use measurement.
How long is the PUSL1 protein?
The Homo sapiens PUSL1 protein (UniProt Q8N0Z8) is 303 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0Z8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0Z8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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