Cell cycle exit and neuronal differentiation protein 1 (CEND1)
Homo sapiens — UniProt Q8N111
Data last refreshed: (UniProt release unknown)
Key facts
Cell cycle exit and neuronal differentiation protein 1 (CEND1) is a protein from Homo sapiens identified by UniProt accession Q8N111, 149 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q8N111; gene symbol CEND1.
- Organism: Homo sapiens.
- Length: 149 amino acids.
- Top disease associations (Open Targets): intraocular pressure measurement, BMI-adjusted waist circumference and Spinocerebellar ataxia type 41.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cell cycle exit and neuronal differentiation protein 1 |
|---|---|
| UniProt accession | Q8N111 |
| Gene | CEND1 |
| Organism | Homo sapiens |
| Length | 149 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- intraocular pressure measurement · score 0.13
- BMI-adjusted waist circumference · score 0.07
- Spinocerebellar ataxia type 41 · score 0.05
- autosomal dominant sensory ataxia 1 · score 0.05
- corneal endothelial cell measurement · score 0.04
- mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations · score 0.04
- spinocerebellar ataxia type 11 · score 0.04
- Dysequilibrium syndrome · score 0.04
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10 · score 0.04
- Autosomal recessive cerebellar ataxia - psychomotor retardation · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N111-F1 | alphafold | PREDICTED | 60.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N111.
Amino-acid sequence (149 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CEND1?
The strongest Open Targets associations for CEND1 are intraocular pressure measurement, BMI-adjusted waist circumference, Spinocerebellar ataxia type 41, autosomal dominant sensory ataxia 1 and corneal endothelial cell measurement.
How long is the CEND1 protein?
The Homo sapiens CEND1 protein (UniProt Q8N111) is 149 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N111 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N111 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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