Keratin-like protein KRT222 (KRT222)
Homo sapiens — UniProt Q8N1A0
Data last refreshed: (UniProt release unknown)
Key facts
Keratin-like protein KRT222 (KRT222) is a protein from Homo sapiens identified by UniProt accession Q8N1A0, 295 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q8N1A0; gene symbol KRT222.
- Organism: Homo sapiens.
- Length: 295 amino acids.
- Top disease associations (Open Targets): asthma, neurodegenerative disease and allergic rhinitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin-like protein KRT222 |
|---|---|
| UniProt accession | Q8N1A0 |
| Gene | KRT222 |
| Organism | Homo sapiens |
| Length | 295 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- asthma · score 0.26
- neurodegenerative disease · score 0.25
- allergic rhinitis · score 0.09
- seasonal allergic rhinitis · score 0.09
- type 1 diabetes mellitus · score 0.08
- childhood onset asthma · score 0.08
- eosinophil count · score 0.06
- serum albumin measurement · score 0.06
- allergic disease · score 0.06
- lymphocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1A0-F1 | alphafold | PREDICTED | 74.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1A0.
Amino-acid sequence (295 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT222?
The strongest Open Targets associations for KRT222 are asthma, neurodegenerative disease, allergic rhinitis, seasonal allergic rhinitis and type 1 diabetes mellitus.
How long is the KRT222 protein?
The Homo sapiens KRT222 protein (UniProt Q8N1A0) is 295 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1A0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1A0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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