Vacuolar protein sorting-associated protein 52 homolog (VPS52)
Homo sapiens — UniProt Q8N1B4
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 52 homolog (VPS52) is a protein from Homo sapiens identified by UniProt accession Q8N1B4, 723 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q8N1B4; gene symbol VPS52.
- Organism: Homo sapiens.
- Length: 723 amino acids.
- Top disease associations (Open Targets): inflammatory spondylopathy, Iridocyclitis and inflammatory bowel disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 52 homolog |
|---|---|
| UniProt accession | Q8N1B4 |
| Gene | VPS52 |
| Organism | Homo sapiens |
| Length | 723 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- inflammatory spondylopathy · score 0.18
- Iridocyclitis · score 0.18
- inflammatory bowel disease · score 0.06
- smoking status measurement · score 0.04
- triple-negative breast cancer · score 0.03
- cervical carcinoma · score 0.02
- acute lymphoblastic leukemia · score 0.01
- infect · score 0.01
- infection · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1B4-F1 | alphafold | PREDICTED | 85.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1B4.
Amino-acid sequence (723 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS52?
The strongest Open Targets associations for VPS52 are inflammatory spondylopathy, Iridocyclitis, inflammatory bowel disease, smoking status measurement and triple-negative breast cancer.
How long is the VPS52 protein?
The Homo sapiens VPS52 protein (UniProt Q8N1B4) is 723 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1B4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1B4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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