Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1)
Homo sapiens — UniProt Q8N1C3
Data last refreshed: (UniProt release unknown)
Key facts
Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1) is a protein from Homo sapiens identified by UniProt accession Q8N1C3, 465 residues long. MolForge cross-references it against 0 known binders and 343 disease associations.
- UniProt accession: Q8N1C3; gene symbol GABRG1.
- Organism: Homo sapiens.
- Length: 465 amino acids.
- Top disease associations (Open Targets): epilepsy, insomnia and unipolar depression.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit gamma-1 |
|---|---|
| UniProt accession | Q8N1C3 |
| Gene | GABRG1 |
| Organism | Homo sapiens |
| Length | 465 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (343)
Diseases linked to this target (Open Targets).
- epilepsy · score 0.61
- insomnia · score 0.60
- unipolar depression · score 0.60
- Agitation · score 0.60
- panic disorder · score 0.60
- pain · score 0.60
- anxiety disorder · score 0.60
- alcohol dependence · score 0.60
- anxiety · score 0.60
- delirium · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1C3-F1 | alphafold | PREDICTED | 78.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1C3.
Amino-acid sequence (465 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GABRG1?
The strongest Open Targets associations for GABRG1 are epilepsy, insomnia, unipolar depression, Agitation and panic disorder.
How long is the GABRG1 protein?
The Homo sapiens GABRG1 protein (UniProt Q8N1C3) is 465 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1C3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1C3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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