F-box/LRR-repeat protein 14 (FBXL14)
Homo sapiens — UniProt Q8N1E6
Data last refreshed: (UniProt release unknown)
Key facts
F-box/LRR-repeat protein 14 (FBXL14) is a protein from Homo sapiens identified by UniProt accession Q8N1E6, 418 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q8N1E6; gene symbol FBXL14.
- Organism: Homo sapiens.
- Length: 418 amino acids.
- Top disease associations (Open Targets): sitting height measurement, vital capacity and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/LRR-repeat protein 14 |
|---|---|
| UniProt accession | Q8N1E6 |
| Gene | FBXL14 |
| Organism | Homo sapiens |
| Length | 418 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- sitting height measurement · score 0.28
- vital capacity · score 0.21
- protein measurement · score 0.20
- clear cell renal carcinoma · score 0.18
- drug use measurement · score 0.12
- Vertigo · score 0.08
- neoplasm · score 0.06
- glioblastoma multiforme · score 0.05
- heel bone mineral density · score 0.04
- body height · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1E6-F1 | alphafold | PREDICTED | 91.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1E6.
Amino-acid sequence (418 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXL14?
The strongest Open Targets associations for FBXL14 are sitting height measurement, vital capacity, protein measurement, clear cell renal carcinoma and drug use measurement.
How long is the FBXL14 protein?
The Homo sapiens FBXL14 protein (UniProt Q8N1E6) is 418 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1E6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1E6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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