RNA exonuclease 1 homolog (REXO1)
Homo sapiens — UniProt Q8N1G1
Data last refreshed: (UniProt release unknown)
Key facts
RNA exonuclease 1 homolog (REXO1) is a protein from Homo sapiens identified by UniProt accession Q8N1G1, 1221 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q8N1G1; gene symbol REXO1.
- Organism: Homo sapiens.
- Length: 1221 amino acids.
- Top disease associations (Open Targets): body mass index, mean corpuscular volume and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA exonuclease 1 homolog |
|---|---|
| UniProt accession | Q8N1G1 |
| Gene | REXO1 |
| Organism | Homo sapiens |
| Length | 1221 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- body mass index · score 0.38
- mean corpuscular volume · score 0.31
- Red cell distribution width · score 0.29
- body fat percentage · score 0.27
- age at menarche · score 0.26
- urate measurement · score 0.26
- lean body mass · score 0.26
- self reported educational attainment · score 0.25
- cardiovascular disease · score 0.25
- bipolar disorder · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1G1-F1 | alphafold | PREDICTED | 57.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1G1.
Amino-acid sequence (1221 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with REXO1?
The strongest Open Targets associations for REXO1 are body mass index, mean corpuscular volume, Red cell distribution width, body fat percentage and age at menarche.
How long is the REXO1 protein?
The Homo sapiens REXO1 protein (UniProt Q8N1G1) is 1221 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1G1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1G1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.