Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (CMTR1)
Homo sapiens — UniProt Q8N1G2
Data last refreshed: (UniProt release unknown)
Key facts
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (CMTR1) is a protein from Homo sapiens identified by UniProt accession Q8N1G2, 835 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q8N1G2; gene symbol CMTR1.
- Organism: Homo sapiens.
- Length: 835 amino acids.
- Top disease associations (Open Targets): smoking behaviour measurement, apolipoprotein A 1 measurement and smoking status measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 |
|---|---|
| UniProt accession | Q8N1G2 |
| Gene | CMTR1 |
| Organism | Homo sapiens |
| Length | 835 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- smoking behaviour measurement · score 0.25
- apolipoprotein A 1 measurement · score 0.24
- smoking status measurement · score 0.23
- substance abuse · score 0.17
- antisocial behaviour measurement · score 0.17
- attention deficit hyperactivity disorder · score 0.17
- smoking behavior · score 0.14
- drug use measurement · score 0.12
- self reported educational attainment · score 0.11
- mathematical ability · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1G2-F1 | alphafold | PREDICTED | 86.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1G2.
Amino-acid sequence (835 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CMTR1?
The strongest Open Targets associations for CMTR1 are smoking behaviour measurement, apolipoprotein A 1 measurement, smoking status measurement, substance abuse and antisocial behaviour measurement.
How long is the CMTR1 protein?
The Homo sapiens CMTR1 protein (UniProt Q8N1G2) is 835 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1G2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1G2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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