Leucine-rich repeat-containing protein 47 (LRRC47)
Homo sapiens — UniProt Q8N1G4
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 47 (LRRC47) is a protein from Homo sapiens identified by UniProt accession Q8N1G4, 583 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q8N1G4; gene symbol LRRC47.
- Organism: Homo sapiens.
- Length: 583 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, reticulocyte count and HbA1c measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 47 |
|---|---|
| UniProt accession | Q8N1G4 |
| Gene | LRRC47 |
| Organism | Homo sapiens |
| Length | 583 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- reticulocyte count · score 0.26
- HbA1c measurement · score 0.22
- Red cell distribution width · score 0.22
- hemoglobin measurement · score 0.22
- Immature Reticulocyte Fraction Measurement · score 0.17
- erythrocyte count · score 0.16
- mean corpuscular hemoglobin concentration · score 0.13
- serum copper measurement · score 0.13
- hematocrit · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1G4-F1 | alphafold | PREDICTED | 76.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1G4.
Amino-acid sequence (583 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC47?
The strongest Open Targets associations for LRRC47 are neurodegenerative disease, reticulocyte count, HbA1c measurement, Red cell distribution width and hemoglobin measurement.
How long is the LRRC47 protein?
The Homo sapiens LRRC47 protein (UniProt Q8N1G4) is 583 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1G4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1G4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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