Protein SIX6OS1 (SIX6OS1)
Homo sapiens — UniProt Q8N1H7
Data last refreshed: (UniProt release unknown)
Key facts
Protein SIX6OS1 (SIX6OS1) is a protein from Homo sapiens identified by UniProt accession Q8N1H7, 587 residues long. MolForge cross-references it against 0 known binders and 182 disease associations.
- UniProt accession: Q8N1H7; gene symbol SIX6OS1.
- Organism: Homo sapiens.
- Length: 587 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 52, azoospermia and Microphthalmia - cataract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein SIX6OS1 |
|---|---|
| UniProt accession | Q8N1H7 |
| Gene | SIX6OS1 |
| Organism | Homo sapiens |
| Length | 587 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (182)
Diseases linked to this target (Open Targets).
- spermatogenic failure 52 · score 0.55
- azoospermia · score 0.49
- Microphthalmia - cataract · score 0.46
- premature ovarian failure 18 · score 0.46
- BMI-adjusted waist-hip ratio · score 0.44
- Developmental cataract · score 0.43
- early-onset non-syndromic cataract · score 0.43
- sclerocornea · score 0.43
- open-angle glaucoma · score 0.42
- refractive error · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1H7-F1 | alphafold | PREDICTED | 58.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1H7.
Amino-acid sequence (587 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIX6OS1?
The strongest Open Targets associations for SIX6OS1 are spermatogenic failure 52, azoospermia, Microphthalmia - cataract, premature ovarian failure 18 and BMI-adjusted waist-hip ratio.
How long is the SIX6OS1 protein?
The Homo sapiens SIX6OS1 protein (UniProt Q8N1H7) is 587 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1H7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1H7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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