Protein THEMIS (THEMIS)
Homo sapiens — UniProt Q8N1K5
Data last refreshed: (UniProt release unknown)
Key facts
Protein THEMIS (THEMIS) is a protein from Homo sapiens identified by UniProt accession Q8N1K5, 641 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.
- UniProt accession: Q8N1K5; gene symbol THEMIS.
- Organism: Homo sapiens.
- Length: 641 amino acids.
- Top disease associations (Open Targets): Crohn's disease, celiac disease and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein THEMIS |
|---|---|
| UniProt accession | Q8N1K5 |
| Gene | THEMIS |
| Organism | Homo sapiens |
| Length | 641 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- Crohn's disease · score 0.39
- celiac disease · score 0.34
- heel bone mineral density · score 0.31
- asthma · score 0.27
- inflammatory bowel disease · score 0.25
- hepcidin:ferritin ratio · score 0.25
- multiple sclerosis · score 0.24
- Hodgkins lymphoma · score 0.21
- seasonal allergic rhinitis · score 0.19
- chronic lymphocytic leukemia · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1K5-F1 | alphafold | PREDICTED | 76.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1K5.
Amino-acid sequence (641 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THEMIS?
The strongest Open Targets associations for THEMIS are Crohn's disease, celiac disease, heel bone mineral density, asthma and inflammatory bowel disease.
How long is the THEMIS protein?
The Homo sapiens THEMIS protein (UniProt Q8N1K5) is 641 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1K5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1K5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.