Bestrophin-3 (BEST3)
Homo sapiens — UniProt Q8N1M1
Data last refreshed: (UniProt release unknown)
Key facts
Bestrophin-3 (BEST3) is a protein from Homo sapiens identified by UniProt accession Q8N1M1, 668 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q8N1M1; gene symbol BEST3.
- Organism: Homo sapiens.
- Length: 668 amino acids.
- Top disease associations (Open Targets): atrial fibrillation, adolescent idiopathic scoliosis and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bestrophin-3 |
|---|---|
| UniProt accession | Q8N1M1 |
| Gene | BEST3 |
| Organism | Homo sapiens |
| Length | 668 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.39
- adolescent idiopathic scoliosis · score 0.28
- PHF-tau measurement · score 0.28
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.12
- astrocytoma · score 0.03
- lung carcinoma · score 0.02
- type 2 diabetes mellitus · score 0.01
- oligodendroglioma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1M1-F1 | alphafold | PREDICTED | 66.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1M1.
Amino-acid sequence (668 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BEST3?
The strongest Open Targets associations for BEST3 are atrial fibrillation, adolescent idiopathic scoliosis, PHF-tau measurement, glioblastoma multiforme and breast adenocarcinoma.
How long is the BEST3 protein?
The Homo sapiens BEST3 protein (UniProt Q8N1M1) is 668 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1M1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1M1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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