Keratin, type II cytoskeletal 78 (KRT78)
Homo sapiens — UniProt Q8N1N4
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type II cytoskeletal 78 (KRT78) is a protein from Homo sapiens identified by UniProt accession Q8N1N4, 520 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q8N1N4; gene symbol KRT78.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, aspartate aminotransferase measurement and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type II cytoskeletal 78 |
|---|---|
| UniProt accession | Q8N1N4 |
| Gene | KRT78 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- aspartate aminotransferase measurement · score 0.22
- head and neck squamous cell carcinoma · score 0.20
- ovarian cancer · score 0.18
- prostate adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- bilirubin measurement · score 0.12
- alkaline phosphatase measurement · score 0.12
- serum gamma-glutamyl transferase measurement · score 0.09
- serum alanine aminotransferase measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1N4-F1 | alphafold | PREDICTED | 69.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1N4.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT78?
The strongest Open Targets associations for KRT78 are neurodegenerative disease, aspartate aminotransferase measurement, head and neck squamous cell carcinoma, ovarian cancer and prostate adenocarcinoma.
How long is the KRT78 protein?
The Homo sapiens KRT78 protein (UniProt Q8N1N4) is 520 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1N4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1N4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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