Beta/gamma crystallin domain-containing protein 2 (CRYBG2)

Homo sapiens — UniProt Q8N1P7

Gene: CRYBG2Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Beta/gamma crystallin domain-containing protein 2 (CRYBG2) is a protein from Homo sapiens identified by UniProt accession Q8N1P7, 1661 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

UniProt accession: Q8N1P7; gene symbol CRYBG2.
Organism: Homo sapiens.
Length: 1661 amino acids.
Top disease associations (Open Targets): balding measurement, brain measurement and monocyte count.
3D structure: AlphaFold model available.

Target properties

Protein name	Beta/gamma crystallin domain-containing protein 2
UniProt accession	Q8N1P7
Gene	CRYBG2
Organism	Homo sapiens
Length	1661 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

balding measurement · score 0.23
brain measurement · score 0.16
monocyte count · score 0.16
PR interval · score 0.16
eosinophil count · score 0.16
monocyte percentage of leukocytes · score 0.13
platelet count · score 0.10
lymphocyte:monocyte ratio · score 0.09
esophageal squamous cell carcinoma · score 0.09
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N1P7-F1	alphafold	PREDICTED	54.55	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1P7.

Amino-acid sequence (1661 residues)

MEEAGGPMAR AKARVVSATL TWRQRPPTQE EIKHGFHKVS LVSGAQMEAP QKEMFEFSRR EEVEVNGFAT QEEETVNCQG PRDTAGSKNF QSHGPIFSKK YIPPPKEKRP EGRLKEAVDQ SDGSRQAPRT EPPCVGAMAR TELLVPLPGP REPSPHPGVG LTSGSSRSLE EYRVTRTVRT TTVVGGHVDR RMSSSVTVRP VSSGEALPRG RQVSRMVPPV VVGSPPGSPS RSQAVKVLSN LVPAGHSPPA SHLPRPTAGG PRSTGLGSTV GAALRQLPET GTAELKDSSA LASTGIPASA HLPKNQDAPA ACPDRDQGRA PDARACELWQ VLGAPSSTEL PLQTSQGQAS VPSSPRLETH VPSPGLTHPA KQPVVPTHPG ARLTPLVLPP KKKDGPVDPP AATVLPMVRS EHVTVPGQPP APSTTRRKDV PSPGGLSAPS SPRNKFVQNS ENVPVLPFTQ REVVKGPGAP AASSPTRKEV VQGSSASAAS SPTWKEVVKG PGAPAASSPT QKEVVQGSSA PAALFPTWKE VVKGPGAPDA SFPTWKEVVK GPGAPAASSP TQKEVVQGSG APAALSTTPK EVVKGPGAPA ASSPTQKEVV KGPCAPAASS PTQKEVVQGS GAPAALSPKS TEVVQGPKGS SSIQKEAVQG IAGSLAPPLT KEETVQGPIA PATSLPKQDK GVQDSEGSPI SSLTQKEVVQ DPDALPAPSS SVDRVSPSPG GTPAPVPTGA EASTESQLVS DPTEGKTCTE TSREEDEVAL AADLEIFLDT LRSMEPPEIL RTHRLPRAPR SSYLSMYATL PAIEEDQLGP WVLGPGPQEV PSLEEKEEEE EEEPENPYLS DDEKLQRRQE KAGPSPSRDL HPARPTQVSC SPLEMMKKHV AGTKGPHSEL GLELQGGSRP TSRLGGSLLF GSLVPTAKEA STPEPLGTKL SALLPHGAPG LRKVPGQLPL LCSERSSPTE KLACSLPLEG WSPALKTQGK LNTRPGKVIF FSESGCQGSG REVWGDIVDA SGWAPVASIR VVRGCWVLYE EPEFRGQKLV LPEGDMELRT PGTKWSPQGI GSLRRVVWDY STPEISLFSE EGLKGEQVKL TEALKNSQGL EKPLQVASAT VSAGLWLLYP KPLFEDTPYI LEPGEYPTSE AWGTSDPSVG SLKPMRLGCP SVEKPGEPRA VVYEAPGFQG RSWEVSRDIY NLQQPEDSQS PHLASVGSLR VLGGCWVGYE KEGFRGHQYL LEEGEYPDWS HWGGYDELLT SLRVIRTDFG DPAVVLFEAM DFEGHGVEVS KALPDVELVQ HGPSTQAIHV LSGVWVAYQE VGFSGEQYVL EKGVYRNCED WGAGNSTLAS LQPVLQVGEH DLHFVSKIQL FSRPDFLGDH FSFEDDQAAL PASFRPQSCR VHGGSWILFD ETNFEGDQHI LSEGEFPTLT AMGCLASTVL GSLQKVSLHF SEPSIFLYGL ECFEGKEIEL SREVRSLQAE GFNNHVLSVR IKGGIWVLCE HSDFRGRQWL VGSCEITNWL TYSGTQRVGS LYPIKQRRVY FRLWNAALGG FLAVPDHVED MKAGRVVVAD PQAGGSCIWY YEDGLLKNQM APTMSLQVIG PPSPGSKVVL WAESRLPRQT WSISESGHIC SQMFEGQILD VKGGRGYDRD HVVLWEPDED RASQIWTIHV L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with CRYBG2?

The strongest Open Targets associations for CRYBG2 are balding measurement, brain measurement, monocyte count, PR interval and eosinophil count.

How long is the CRYBG2 protein?

The Homo sapiens CRYBG2 protein (UniProt Q8N1P7) is 1661 amino acids long.

Browse: Targets: C · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q8N1P7 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q8N1P7 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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