Acyl-coenzyme A thioesterase THEM5 (THEM5)
Homo sapiens — UniProt Q8N1Q8
Data last refreshed: (UniProt release unknown)
Key facts
Acyl-coenzyme A thioesterase THEM5 (THEM5) is a protein from Homo sapiens identified by UniProt accession Q8N1Q8, 247 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: Q8N1Q8; gene symbol THEM5.
- Organism: Homo sapiens.
- Length: 247 amino acids.
- Top disease associations (Open Targets): monocyte count, metabolite measurement and neonatal intrahepatic cholestasis due to citrin deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyl-coenzyme A thioesterase THEM5 |
|---|---|
| UniProt accession | Q8N1Q8 |
| Gene | THEM5 |
| Organism | Homo sapiens |
| Length | 247 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.22
- metabolite measurement · score 0.12
- neonatal intrahepatic cholestasis due to citrin deficiency · score 0.03
- myelodysplastic syndrome · score 0.00
- neoplasm · score 0.00
- cutaneous lupus erythematosus · score 0.00
- papillary thyroid carcinoma · score 0.00
- hepatocellular carcinoma · score 0.00
- Obesity · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1Q8-F1 | alphafold | PREDICTED | 83.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1Q8.
Amino-acid sequence (247 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THEM5?
The strongest Open Targets associations for THEM5 are monocyte count, metabolite measurement, neonatal intrahepatic cholestasis due to citrin deficiency, myelodysplastic syndrome and neoplasm.
How long is the THEM5 protein?
The Homo sapiens THEM5 protein (UniProt Q8N1Q8) is 247 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1Q8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1Q8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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