Cilia- and flagella-associated protein 52 (CFAP52)
Homo sapiens — UniProt Q8N1V2
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 52 (CFAP52) is a protein from Homo sapiens identified by UniProt accession Q8N1V2, 620 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q8N1V2; gene symbol CFAP52.
- Organism: Homo sapiens.
- Length: 620 amino acids.
- Top disease associations (Open Targets): Situs inversus totalis, heterotaxy, visceral, 9, autosomal, with male infertility and visceral heterotaxy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 52 |
|---|---|
| UniProt accession | Q8N1V2 |
| Gene | CFAP52 |
| Organism | Homo sapiens |
| Length | 620 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- Situs inversus totalis · score 0.45
- heterotaxy, visceral, 9, autosomal, with male infertility · score 0.43
- visceral heterotaxy · score 0.37
- situs inversus · score 0.34
- Oculomotor apraxia · score 0.12
- asthma · score 0.07
- Limb pain · score 0.07
- blood protein measurement · score 0.06
- uric acid measurement · score 0.06
- white matter microstructure measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N1V2-F1 | alphafold | PREDICTED | 93.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1V2.
Amino-acid sequence (620 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP52?
The strongest Open Targets associations for CFAP52 are Situs inversus totalis, heterotaxy, visceral, 9, autosomal, with male infertility, visceral heterotaxy, situs inversus and Oculomotor apraxia.
How long is the CFAP52 protein?
The Homo sapiens CFAP52 protein (UniProt Q8N1V2) is 620 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N1V2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N1V2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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