Rho guanine nucleotide exchange factor 28 (ARHGEF28)

Homo sapiens — UniProt Q8N1W1

Gene: ARHGEF28Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Rho guanine nucleotide exchange factor 28 (ARHGEF28) is a protein from Homo sapiens identified by UniProt accession Q8N1W1, 1705 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

UniProt accession: Q8N1W1; gene symbol ARHGEF28.
Organism: Homo sapiens.
Length: 1705 amino acids.
Top disease associations (Open Targets): sex hormone-binding globulin measurement, reticulocyte count and age-related hearing impairment.
3D structure: AlphaFold model available.

Target properties

Protein name	Rho guanine nucleotide exchange factor 28
UniProt accession	Q8N1W1
Gene	ARHGEF28
Organism	Homo sapiens
Length	1705 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.45
reticulocyte count · score 0.45
age-related hearing impairment · score 0.44
C-reactive protein measurement · score 0.42
serum alanine aminotransferase measurement · score 0.38
apolipoprotein A 1 measurement · score 0.38
diet measurement · score 0.37
mean corpuscular volume · score 0.36
reticulocyte measurement · score 0.36
hearing loss · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N1W1-F1	alphafold	PREDICTED	61.57	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N1W1.

Amino-acid sequence (1705 residues)

MELSCSEAPL YGQMMIYAKF DKNVYLPEDA EFYFTYDGSH QRHVMIAERI EDNVLQSSVP GHGLQETVTV SVCLCSEGYS PVTMGSGSVT YVDNMACRLA RLLVTQANRL TACSHQTLLT PFALTAGALP ALDEELVLAL THLELPLEWT VLGSSSLEVS SHRESLLHLA MRWGLAKLSQ FFLCLPGGVQ ALALPNEEGA TPLDLALREG HSKLVEDVTN FQGRWSPSFS RVQLSEEASL HYIHSSETLT LTLNHTAEHL LEADIKLFRK YFWDRAFLVK AFEPEARPEE RTAMPSSGAE TEEEIKNSVS SRSAAEKEDI KRVKSLVVQH NEHEDQHSLD LDRSFDILKK SKPPSTLLAA GRLSDMLNGG DEVYANCMVI DQVGDLDISY INIEGITATT SPESRGCTLW PQSSKHTLPT ETSPSVYPLS ENVEGTAHTE AQQSFMSPSS SCASNLNLSF GWHGFEKEQS HLKKRSSSLD ALDADSEGEG HSEPSHICYT PGSQSSSRTG IPSGDELDSF ETNTEPDFNI SRAESLPLSS NLQSKESLLS GVRSRSYSCS SPKISLGKTR LVRELTVCSS SEEQRAYSLS EPPRENRIQE EEWDKYIIPA KSESEKYKVS RTFSFLMNRM TSPRNKSKTK SKDAKDKEKL NRHQFAPGTF SGVLQCLVCD KTLLGKESLQ CSNCNANVHK GCKDAAPACT KKFQEKYNKN KPQTILGNSS FRDIPQPGLS LHPSSSVPVG LPTGRRETVG QVHPLSRSVP GTTLESFRRS ATSLESESDH NSCRSRSHSD ELLQSMGSSP STESFIMEDV VDSSLWSDLS SDAQEFEAES WSLVVDPSFC NRQEKDVIKR QDVIFELMQT EMHHIQTLFI MSEIFRKGMK EELQLDHSTV DKIFPCLDEL LEIHRHFFYS MKERRQESCA GSDRNFVIDR IGDILVQQFS EENASKMKKI YGEFCCHHKE AVNLFKELQQ NKKFQNFIKL RNSNLLARRR GIPECILLVT QRITKYPVLV ERILQYTKER TEEHKDLRKA LCLIKDMIAT VDLKVNEYEK NQKWLEILNK IENKTYTKLK NGHVFRKQAL MSEERTLLYD GLVYWKTATG RFKDILALLL TDVLLFLQEK DQKYIFAAVD QKPSVISLQK LIAREVANEE RGMFLISASS AGPEMYEIHT NSKEERNNWM RRIQQAVESC PEEKGGRTSE SDEDKRKAEA RVAKIQQCQE ILTNQDQQIC AYLEEKLHIY AELGELSGFE DVHLEPHLLI KPDPGEPPQA ASLLAAALKE AESLQVAVKA SQMGAVSQSC EDSCGDSVLA DTLSSHDVPG SPTASLVTGG REGRGCSDVD PGIQGVVTDL AVSDAGEKVE CRNFPGSSQS EIIQAIQNLT RLLYSLQAAL TIQDSHIEIH RLVLQQQEGL SLGHSILRGG PLQDQKSRDA DRQHEELANV HQLQHQLQQE QRRWLRRCEQ QQRAQATRES WLQERERECQ SQEELLLRSR GELDLQLQEY QHSLERLREG QRLVEREQAR MRAQQSLLGH WKHGRQRSLP AVLLPGGPEV MELNRSESLC HENSFFINEA LVQMSFNTFN KLNPSVIHQD ATYPTTQSHS DLVRTSEHQV DLKVDPSQPS NVSHKLWTAA GSGHQILPFH ESSKDSCKND LDTSHTESPT PHDSNSHRPQ LQAFITEAKL NLPTRTMTRQ DGETGDGAKE NIVYL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with ARHGEF28?

The strongest Open Targets associations for ARHGEF28 are sex hormone-binding globulin measurement, reticulocyte count, age-related hearing impairment, C-reactive protein measurement and serum alanine aminotransferase measurement.

How long is the ARHGEF28 protein?

The Homo sapiens ARHGEF28 protein (UniProt Q8N1W1) is 1705 amino acids long.

Browse: Targets: A · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q8N1W1 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q8N1W1 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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