Mitochondrial cardiolipin hydrolase (PLD6)
Homo sapiens — UniProt Q8N2A8
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial cardiolipin hydrolase (PLD6) is a protein from Homo sapiens identified by UniProt accession Q8N2A8, 252 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.
- UniProt accession: Q8N2A8; gene symbol PLD6.
- Organism: Homo sapiens.
- Length: 252 amino acids.
- Top disease associations (Open Targets): male infertility, breast adenocarcinoma and hematocrit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial cardiolipin hydrolase |
|---|---|
| UniProt accession | Q8N2A8 |
| Gene | PLD6 |
| Organism | Homo sapiens |
| Length | 252 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (130)
Diseases linked to this target (Open Targets).
- male infertility · score 0.30
- breast adenocarcinoma · score 0.20
- hematocrit · score 0.12
- hemoglobin measurement · score 0.11
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- heel bone mineral density · score 0.08
- serum alanine aminotransferase measurement · score 0.08
- mean corpuscular hemoglobin concentration · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N2A8-F1 | alphafold | PREDICTED | 83.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2A8.
Amino-acid sequence (252 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLD6?
The strongest Open Targets associations for PLD6 are male infertility, breast adenocarcinoma, hematocrit, hemoglobin measurement and azoospermia.
How long is the PLD6 protein?
The Homo sapiens PLD6 protein (UniProt Q8N2A8) is 252 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N2A8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N2A8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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