E3 ubiquitin-protein ligase pellino homolog 3 (PELI3)
Homo sapiens — UniProt Q8N2H9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase pellino homolog 3 (PELI3) is a protein from Homo sapiens identified by UniProt accession Q8N2H9, 469 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q8N2H9; gene symbol PELI3.
- Organism: Homo sapiens.
- Length: 469 amino acids.
- Top disease associations (Open Targets): erythrocyte count, breast adenocarcinoma and non-small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase pellino homolog 3 |
|---|---|
| UniProt accession | Q8N2H9 |
| Gene | PELI3 |
| Organism | Homo sapiens |
| Length | 469 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.10
- breast adenocarcinoma · score 0.10
- non-small cell lung carcinoma · score 0.08
- low density lipoprotein cholesterol measurement · score 0.06
- benign prostatic hyperplasia · score 0.06
- Testicular regression syndrome · score 0.05
- apolipoprotein B measurement · score 0.04
- 46,XX ovotesticular disorder of sex development · score 0.04
- neoplasm · score 0.04
- total cholesterol measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N2H9-F1 | alphafold | PREDICTED | 81.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2H9.
Amino-acid sequence (469 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PELI3?
The strongest Open Targets associations for PELI3 are erythrocyte count, breast adenocarcinoma, non-small cell lung carcinoma, low density lipoprotein cholesterol measurement and benign prostatic hyperplasia.
How long is the PELI3 protein?
The Homo sapiens PELI3 protein (UniProt Q8N2H9) is 469 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N2H9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N2H9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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