Serine/threonine-protein kinase 40 (STK40)
Homo sapiens — UniProt Q8N2I9
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase 40 (STK40) is a protein from Homo sapiens identified by UniProt accession Q8N2I9, 435 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8N2I9; gene symbol STK40.
- Organism: Homo sapiens.
- Length: 435 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and surfactant metabolism dysfunction, pulmonary, 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase 40 |
|---|---|
| UniProt accession | Q8N2I9 |
| Gene | STK40 |
| Organism | Homo sapiens |
| Length | 435 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- neuroinflammatory disorder · score 0.46
- surfactant metabolism dysfunction, pulmonary, 1 · score 0.06
- interstitial lung disease · score 0.05
- Neonatal acute respiratory distress with surfactant metabolism deficiency · score 0.05
- Congenital pulmonary alveolar proteinosis · score 0.05
- idiopathic pulmonary fibrosis · score 0.05
- familial primary pulmonary hypoplasia · score 0.05
- autoimmune pulmonary alveolar proteinosis · score 0.05
- neuroticism measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N2I9-F1 | alphafold | PREDICTED | 77.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2I9.
Amino-acid sequence (435 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with STK40?
The strongest Open Targets associations for STK40 are neurodegenerative disease, neuroinflammatory disorder, surfactant metabolism dysfunction, pulmonary, 1, interstitial lung disease and Neonatal acute respiratory distress with surfactant metabolism deficiency.
How long is the STK40 protein?
The Homo sapiens STK40 protein (UniProt Q8N2I9) is 435 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N2I9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N2I9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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