Ubiquitin-conjugating enzyme E2 J2 (UBE2J2)
Homo sapiens — UniProt Q8N2K1
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin-conjugating enzyme E2 J2 (UBE2J2) is a protein from Homo sapiens identified by UniProt accession Q8N2K1, 259 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q8N2K1; gene symbol UBE2J2.
- Organism: Homo sapiens.
- Length: 259 amino acids.
- Top disease associations (Open Targets): clear cell renal carcinoma, hemoglobin D disease and dehydrated hereditary stomatocytosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 J2 |
|---|---|
| UniProt accession | Q8N2K1 |
| Gene | UBE2J2 |
| Organism | Homo sapiens |
| Length | 259 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- clear cell renal carcinoma · score 0.18
- hemoglobin D disease · score 0.05
- dehydrated hereditary stomatocytosis · score 0.05
- dominant beta-thalassemia · score 0.04
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.04
- erythroleukemia, familial, susceptibility to · score 0.04
- overhydrated hereditary stomatocytosis · score 0.04
- X-linked sideroblastic anemia 1 · score 0.03
- thrombocytopenia 7 · score 0.03
- monosomy 7 myelodysplasia and leukemia syndrome 1 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N2K1-F1 | alphafold | PREDICTED | 84.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2K1.
Amino-acid sequence (259 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBE2J2?
The strongest Open Targets associations for UBE2J2 are clear cell renal carcinoma, hemoglobin D disease, dehydrated hereditary stomatocytosis, dominant beta-thalassemia and beta-thalassemia-X-linked thrombocytopenia syndrome.
How long is the UBE2J2 protein?
The Homo sapiens UBE2J2 protein (UniProt Q8N2K1) is 259 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N2K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N2K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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