Neuroligin-1 (NLGN1)
Homo sapiens — UniProt Q8N2Q7
Data last refreshed: (UniProt release unknown)
Key facts
Neuroligin-1 (NLGN1) is a protein from Homo sapiens identified by UniProt accession Q8N2Q7, 863 residues long. MolForge cross-references it against 0 known binders and 131 disease associations.
- UniProt accession: Q8N2Q7; gene symbol NLGN1.
- Organism: Homo sapiens.
- Length: 863 amino acids.
- Top disease associations (Open Targets): body mass index, body fat percentage and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuroligin-1 |
|---|---|
| UniProt accession | Q8N2Q7 |
| Gene | NLGN1 |
| Organism | Homo sapiens |
| Length | 863 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (131)
Diseases linked to this target (Open Targets).
- body mass index · score 0.45
- body fat percentage · score 0.44
- lean body mass · score 0.43
- fat body mass · score 0.41
- smoking status measurement · score 0.40
- type 2 diabetes mellitus · score 0.39
- body weight · score 0.37
- insomnia measurement · score 0.36
- smoking initiation · score 0.34
- frailty measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N2Q7-F1 | alphafold | PREDICTED | 77.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2Q7.
Amino-acid sequence (863 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NLGN1?
The strongest Open Targets associations for NLGN1 are body mass index, body fat percentage, lean body mass, fat body mass and smoking status measurement.
How long is the NLGN1 protein?
The Homo sapiens NLGN1 protein (UniProt Q8N2Q7) is 863 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N2Q7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N2Q7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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