Latent-transforming growth factor beta-binding protein 4 (LTBP4)

Homo sapiens — UniProt Q8N2S1

Gene: LTBP4Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Latent-transforming growth factor beta-binding protein 4 (LTBP4) is a protein from Homo sapiens identified by UniProt accession Q8N2S1, 1624 residues long. MolForge cross-references it against 0 known binders and 273 disease associations.

UniProt accession: Q8N2S1; gene symbol LTBP4.
Organism: Homo sapiens.
Length: 1624 amino acids.
Top disease associations (Open Targets): cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies, Duchenne muscular dystrophy and vital capacity.
3D structure: AlphaFold model available.

Target properties

Protein name	Latent-transforming growth factor beta-binding protein 4
UniProt accession	Q8N2S1
Gene	LTBP4
Organism	Homo sapiens
Length	1624 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (273)

Diseases linked to this target (Open Targets).

cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies · score 0.74
Duchenne muscular dystrophy · score 0.42
vital capacity · score 0.35
FEV/FVC ratio · score 0.35
body height · score 0.34
erythrocyte count · score 0.31
hemoglobin measurement · score 0.30
hematocrit · score 0.28
cutis laxa · score 0.27
systolic blood pressure · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N2S1-F1	alphafold	PREDICTED	62.49	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2S1.

Amino-acid sequence (1624 residues)

MPRPGTSGRR PLLLVLLLPL FAAATSAASP SPSPSQVVEV PGVPSRPASV AVCRCCPGQT SRRSRCIRAF CRVRSCQPKK CAGPQRCLNP VPAVPSPSPS VRKRQVSLNW QPLTLQEARA LLKRRRPRGP GGRGLLRRRP PQRAPAGKAP VLCPLICHNG GVCVKPDRCL CPPDFAGKFC QLHSSGARPP APAVPGLTRS VYTMPLANHR DDEHGVASMV SVHVEHPQEA SVVVHQVERV SGPWEEADAE AVARAEAAAR AEAAAPYTVL AQSAPREDGY SDASGFGYCF RELRGGECAS PLPGLRTQEV CCRGAGLAWG VHDCQLCSER LGNSERVSAP DGPCPTGFER VNGSCEDVDE CATGGRCQHG ECANTRGGYT CVCPDGFLLD SSRSSCISQH VISEAKGPCF RVLRDGGCSL PILRNITKQI CCCSRVGKAW GRGCQLCPPF GSEGFREICP AGPGYHYSAS DLRYNTRPLG QEPPRVSLSQ PRTLPATSRP SAGFLPTHRL EPRPEPRPDP RPGPELPLPS IPAWTGPEIP ESGPSSGMCQ RNPQVCGPGR CISRPSGYTC ACDSGFRLSP QGTRCIDVDE CRRVPPPCAP GRCENSPGSF RCVCGPGFRA GPRAAECLDV DECHRVPPPC DLGRCENTPG SFLCVCPAGY QAAPHGASCQ DVDECTQSPG LCGRGACKNL PGSFRCVCPA GFRGSACEED VDECAQEPPP CGPGRCDNTA GSFHCACPAG FRSRGPGAPC QDVDECARSP PPCTYGRCEN TEGSFQCVCP MGFQPNTAGS ECEDVDECEN HLACPGQECV NSPGSFQCRT CPSGHHLHRG RCTDVDECSS GAPPCGPHGH CTNTEGSFRC SCAPGYRAPS GRPGPCADVN ECLEGDFCFP HGECLNTDGS FACTCAPGYR PGPRGASCLD VDECSEEDLC QSGICTNTDG SFECICPPGH RAGPDLASCL DVDECRERGP ALCGSQRCEN SPGSYRCVRD CDPGYHAGPE GTCDDVDECQ EYGPEICGAQ RCENTPGSYR CTPACDPGYQ PTPGGGCQDV DECRNRSFCG AHAVCQNLPG SFQCLCDQGY EGARDGRHCV DVNECETLQG VCGAALCENV EGSFLCVCPN SPEEFDPMTG RCVPPRTSAG TFPGSQPQAP ASPVLPARPP PPPLPRRPST PRQGPVGSGR RECYFDTAAP DACDNILARN VTWQECCCTV GEGWGSGCRI QQCPGTETAE YQSLCPHGRG YLAPSGDLSL RRDVDECQLF RDQVCKSGVC VNTAPGYSCY CSNGYYYHTQ RLECIDNDEC ADEEPACEGG RCVNTVGSYH CTCEPPLVLD GSQRRCVSNE SQSLDDNLGV CWQEVGADLV CSHPRLDRQA TYTECCCLYG EAWGMDCALC PAQDSDDFEA LCNVLRPPAY SPPRPGGFGL PYEYGPDLGP PYQGLPYGPE LYPPPALPYD PYPPPPGPFA RREAPYGAPR FDMPDFEDDG GPYGESEAPA PPGPGTRWPY RSRDTRRSFP EPEEPPEGGS YAGSLAEPYE ELEAEECGIL DGCTNGRCVR VPEGFTCRCF DGYRLDMTRM ACVDINECDE AEAASPLCVN ARCLNTDGSF RCICRPGFAP THQPHHCAPA RPRA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with LTBP4?

The strongest Open Targets associations for LTBP4 are cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies, Duchenne muscular dystrophy, vital capacity, FEV/FVC ratio and body height.

How long is the LTBP4 protein?

The Homo sapiens LTBP4 protein (UniProt Q8N2S1) is 1624 amino acids long.

Browse: Targets: L · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q8N2S1 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q8N2S1 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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