Transmembrane protein 256 (TMEM256)
Homo sapiens — UniProt Q8N2U0
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 256 (TMEM256) is a protein from Homo sapiens identified by UniProt accession Q8N2U0, 113 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q8N2U0; gene symbol TMEM256.
- Organism: Homo sapiens.
- Length: 113 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, Short rib-polydactyly syndrome, Verma-Naumoff type and asphyxiating thoracic dystrophy 3.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 256 |
|---|---|
| UniProt accession | Q8N2U0 |
| Gene | TMEM256 |
| Organism | Homo sapiens |
| Length | 113 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.31
- Short rib-polydactyly syndrome, Verma-Naumoff type · score 0.26
- asphyxiating thoracic dystrophy 3 · score 0.26
- short rib-polydactyly syndrome, Majewski type · score 0.26
- blood protein measurement · score 0.06
- hemoglobin D disease · score 0.04
- ghosal hematodiaphyseal dysplasia · score 0.04
- Wolff-Parkinson-White Syndrome · score 0.04
- Weismann-Netter syndrome · score 0.04
- hemoglobin E disease · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N2U0-F1 | alphafold | PREDICTED | 95.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2U0.
Amino-acid sequence (113 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM256?
The strongest Open Targets associations for TMEM256 are sex hormone-binding globulin measurement, Short rib-polydactyly syndrome, Verma-Naumoff type, asphyxiating thoracic dystrophy 3, short rib-polydactyly syndrome, Majewski type and blood protein measurement.
How long is the TMEM256 protein?
The Homo sapiens TMEM256 protein (UniProt Q8N2U0) is 113 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N2U0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N2U0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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