E3 SUMO-protein ligase PIAS4 (PIAS4)
Homo sapiens — UniProt Q8N2W9
Data last refreshed: (UniProt release unknown)
Key facts
E3 SUMO-protein ligase PIAS4 (PIAS4) is a protein from Homo sapiens identified by UniProt accession Q8N2W9, 510 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8N2W9; gene symbol PIAS4.
- Organism: Homo sapiens.
- Length: 510 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, neurodegenerative disease and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 SUMO-protein ligase PIAS4 |
|---|---|
| UniProt accession | Q8N2W9 |
| Gene | PIAS4 |
| Organism | Homo sapiens |
| Length | 510 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.28
- neurodegenerative disease · score 0.28
- endometrial cancer · score 0.28
- glioblastoma multiforme · score 0.28
- esophageal cancer · score 0.27
- pancreatic adenocarcinoma · score 0.27
- head and neck squamous cell carcinoma · score 0.26
- squamous cell lung carcinoma · score 0.25
- gastric adenocarcinoma · score 0.25
- urinary bladder cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N2W9-F1 | alphafold | PREDICTED | 76.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N2W9.
Amino-acid sequence (510 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIAS4?
The strongest Open Targets associations for PIAS4 are breast adenocarcinoma, neurodegenerative disease, endometrial cancer, glioblastoma multiforme and esophageal cancer.
How long is the PIAS4 protein?
The Homo sapiens PIAS4 protein (UniProt Q8N2W9) is 510 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N2W9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N2W9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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