Mesoderm induction early response protein 2 (MIER2)
Homo sapiens — UniProt Q8N344
Data last refreshed: (UniProt release unknown)
Key facts
Mesoderm induction early response protein 2 (MIER2) is a protein from Homo sapiens identified by UniProt accession Q8N344, 545 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.
- UniProt accession: Q8N344; gene symbol MIER2.
- Organism: Homo sapiens.
- Length: 545 amino acids.
- Top disease associations (Open Targets): lymphocyte count, lymphocyte percentage of leukocytes and monocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mesoderm induction early response protein 2 |
|---|---|
| UniProt accession | Q8N344 |
| Gene | MIER2 |
| Organism | Homo sapiens |
| Length | 545 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (5)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.31
- lymphocyte percentage of leukocytes · score 0.07
- monocyte percentage of leukocytes · score 0.03
- renal cell carcinoma · score 0.02
- cardiac hypertrophy · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N344-F1 | alphafold | PREDICTED | 57.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N344.
Amino-acid sequence (545 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MIER2?
The strongest Open Targets associations for MIER2 are lymphocyte count, lymphocyte percentage of leukocytes, monocyte percentage of leukocytes, renal cell carcinoma and cardiac hypertrophy.
How long is the MIER2 protein?
The Homo sapiens MIER2 protein (UniProt Q8N344) is 545 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N344 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N344 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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