Protein mono-ADP-ribosyltransferase PARP8 (PARP8)
Homo sapiens — UniProt Q8N3A8
Data last refreshed: (UniProt release unknown)
Key facts
Protein mono-ADP-ribosyltransferase PARP8 (PARP8) is a protein from Homo sapiens identified by UniProt accession Q8N3A8, 854 residues long. MolForge cross-references it against 3 known binders and 55 disease associations.
- UniProt accession: Q8N3A8; gene symbol PARP8.
- Organism: Homo sapiens.
- Length: 854 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, COVID-19 and severe acute respiratory syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase PARP8 |
|---|---|
| UniProt accession | Q8N3A8 |
| Gene | PARP8 |
| Organism | Homo sapiens |
| Length | 854 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.46
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- neuroblastoma · score 0.34
- eosinophil count · score 0.28
- heel bone mineral density · score 0.26
- breast carcinoma · score 0.24
- risk-taking behaviour · score 0.21
- myeloid white cell count · score 0.16
- metabolite measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3A8-F1 | alphafold | PREDICTED | 65.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3A8.
Amino-acid sequence (854 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PARP8?
The strongest Open Targets associations for PARP8 are type 2 diabetes mellitus, COVID-19, severe acute respiratory syndrome, neuroblastoma and eosinophil count.
How long is the PARP8 protein?
The Homo sapiens PARP8 protein (UniProt Q8N3A8) is 854 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3A8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3A8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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