1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (PLCD3)
Homo sapiens — UniProt Q8N3E9
Data last refreshed: (UniProt release unknown)
Key facts
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (PLCD3) is a protein from Homo sapiens identified by UniProt accession Q8N3E9, 789 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: Q8N3E9; gene symbol PLCD3.
- Organism: Homo sapiens.
- Length: 789 amino acids.
- Top disease associations (Open Targets): sitting height measurement, appendicular lean mass and hypertension.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 |
|---|---|
| UniProt accession | Q8N3E9 |
| Gene | PLCD3 |
| Organism | Homo sapiens |
| Length | 789 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- sitting height measurement · score 0.34
- appendicular lean mass · score 0.31
- hypertension · score 0.29
- body height · score 0.28
- BMI-adjusted hip circumference · score 0.27
- triglyceride measurement · score 0.26
- cutaneous melanoma · score 0.19
- systolic blood pressure · score 0.15
- breast adenocarcinoma · score 0.13
- pulse pressure measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3E9-F1 | alphafold | PREDICTED | 85.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3E9.
Amino-acid sequence (789 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLCD3?
The strongest Open Targets associations for PLCD3 are sitting height measurement, appendicular lean mass, hypertension, body height and BMI-adjusted hip circumference.
How long is the PLCD3 protein?
The Homo sapiens PLCD3 protein (UniProt Q8N3E9) is 789 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3E9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3E9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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