Integral membrane protein GPR137C (GPR137C)
Homo sapiens — UniProt Q8N3F9
Data last refreshed: (UniProt release unknown)
Key facts
Integral membrane protein GPR137C (GPR137C) is a protein from Homo sapiens identified by UniProt accession Q8N3F9, 429 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q8N3F9; gene symbol GPR137C.
- Organism: Homo sapiens.
- Length: 429 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, urinary metabolite measurement and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Integral membrane protein GPR137C |
|---|---|
| UniProt accession | Q8N3F9 |
| Gene | GPR137C |
| Organism | Homo sapiens |
| Length | 429 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.21
- urinary metabolite measurement · score 0.11
- serum metabolite measurement · score 0.05
- prostate carcinoma · score 0.04
- sitting height measurement · score 0.02
- Ataxia-telangiectasia · score 0.02
- small cell lung carcinoma · score 0.01
- uterine leiomyosarcoma · score 0.01
- neoplasm · score 0.00
- Friedreich ataxia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3F9-F1 | alphafold | PREDICTED | 66.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3F9.
Amino-acid sequence (429 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR137C?
The strongest Open Targets associations for GPR137C are heel bone mineral density, urinary metabolite measurement, serum metabolite measurement, prostate carcinoma and sitting height measurement.
How long is the GPR137C protein?
The Homo sapiens GPR137C protein (UniProt Q8N3F9) is 429 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3F9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3F9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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