Integral membrane protein GPR137C (GPR137C)

About Integral membrane protein GPR137C

Integral membrane protein GPR137C (GPR137C) is a protein from Homo sapiens identified by UniProt accession Q8N3F9, 429 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Integral membrane protein GPR137C
UniProt accession	Q8N3F9
Gene	GPR137C
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.21
urinary metabolite measurement · score 0.11
serum metabolite measurement · score 0.05
prostate carcinoma · score 0.04
sitting height measurement · score 0.02
Ataxia-telangiectasia · score 0.02
small cell lung carcinoma · score 0.01
uterine leiomyosarcoma · score 0.01
neoplasm · score 0.00
Friedreich ataxia · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N3F9-F1	alphafold	PREDICTED	66.57	—

Amino-acid sequence (429 residues)

MRVSVPGPAA AAAPAAGREP STPGGGSGGG GAVAAASGAA VPGSVQLALS VLHALLYAAL FAFAYLQLWR LLLYRERRLS YQSLCLFLCL LWAALRTTLF SAAFSLSGSL PLLRPPAHLH FFPHWLLYCF PSCLQFSTLC LLNLYLAEVI CKVRCATELD RHKILLHLGF IMASLLFLVV NLTCAMLVHG DVPENQLKWT VFVRALINDS LFILCAISLV CYICKITKMS SANVYLESKG MSLCQTVVVG SVVILLYSSR ACYNLVVVTI SQDTLESPFN YGWDNLSDKA HVEDISGEEY IVFGMVLFLW EHVPAWSVVL FFRAQRLNQN LAPAGMINSH SYSSRAYFFD NPRRYDSDDD LPRLGSSREG SLPNSQSLGW YGTMTGCGSS SYTVTPHLNG PMTDTAPLLF TCSNLDLNNH HSLYVTPQN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards