Transmembrane protein 130 (TMEM130)
Homo sapiens — UniProt Q8N3G9
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 130 (TMEM130) is a protein from Homo sapiens identified by UniProt accession Q8N3G9, 435 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q8N3G9; gene symbol TMEM130.
- Organism: Homo sapiens.
- Length: 435 amino acids.
- Top disease associations (Open Targets): erythrocyte count, mean corpuscular volume and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 130 |
|---|---|
| UniProt accession | Q8N3G9 |
| Gene | TMEM130 |
| Organism | Homo sapiens |
| Length | 435 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.18
- mean corpuscular volume · score 0.15
- mean corpuscular hemoglobin · score 0.11
- mean reticulocyte volume · score 0.10
- red blood cell density measurement · score 0.08
- mean corpuscular hemoglobin concentration · score 0.05
- glioblastoma multiforme · score 0.05
- atypical teratoid rhabdoid tumor · score 0.04
- central nervous system cancer · score 0.04
- ependymoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3G9-F1 | alphafold | PREDICTED | 78.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3G9.
Amino-acid sequence (435 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM130?
The strongest Open Targets associations for TMEM130 are erythrocyte count, mean corpuscular volume, mean corpuscular hemoglobin, mean reticulocyte volume and red blood cell density measurement.
How long is the TMEM130 protein?
The Homo sapiens TMEM130 protein (UniProt Q8N3G9) is 435 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3G9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3G9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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