BBSome complex member BBS5 (BBS5)
Homo sapiens — UniProt Q8N3I7
Data last refreshed: (UniProt release unknown)
Key facts
BBSome complex member BBS5 (BBS5) is a protein from Homo sapiens identified by UniProt accession Q8N3I7, 341 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q8N3I7; gene symbol BBS5.
- Organism: Homo sapiens.
- Length: 341 amino acids.
- Top disease associations (Open Targets): Bardet-Biedl syndrome 5, Bardet-Biedl syndrome and polydactyly.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BBSome complex member BBS5 |
|---|---|
| UniProt accession | Q8N3I7 |
| Gene | BBS5 |
| Organism | Homo sapiens |
| Length | 341 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome 5 · score 0.80
- Bardet-Biedl syndrome · score 0.66
- polydactyly · score 0.46
- Polydactyly · score 0.46
- Bardet-Biedl syndrome 1 · score 0.46
- ciliopathy · score 0.37
- Obesity · score 0.37
- obesity · score 0.37
- neurodegenerative disease · score 0.34
- cone dystrophy · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3I7-F1 | alphafold | PREDICTED | 88.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3I7.
Amino-acid sequence (341 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BBS5?
The strongest Open Targets associations for BBS5 are Bardet-Biedl syndrome 5, Bardet-Biedl syndrome, polydactyly, Polydactyly and Bardet-Biedl syndrome 1.
How long is the BBS5 protein?
The Homo sapiens BBS5 protein (UniProt Q8N3I7) is 341 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3I7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3I7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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