Homologous recombination OB-fold protein (HROB)
Homo sapiens — UniProt Q8N3J3
Data last refreshed: (UniProt release unknown)
Key facts
Homologous recombination OB-fold protein (HROB) is a protein from Homo sapiens identified by UniProt accession Q8N3J3, 647 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8N3J3; gene symbol HROB.
- Organism: Homo sapiens.
- Length: 647 amino acids.
- Top disease associations (Open Targets): Premature ovarian insufficiency, bone quantitative ultrasound measurement and bipolar disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homologous recombination OB-fold protein |
|---|---|
| UniProt accession | Q8N3J3 |
| Gene | HROB |
| Organism | Homo sapiens |
| Length | 647 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- Premature ovarian insufficiency · score 0.26
- bone quantitative ultrasound measurement · score 0.25
- bipolar disorder · score 0.20
- body fat distribution · score 0.20
- femoral neck bone mineral density · score 0.18
- visceral adipose tissue measurement · score 0.16
- appendicular lean mass · score 0.16
- calcium measurement · score 0.15
- urate measurement · score 0.15
- HbA1c measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3J3-F1 | alphafold | PREDICTED | 54.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3J3.
Amino-acid sequence (647 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HROB?
The strongest Open Targets associations for HROB are Premature ovarian insufficiency, bone quantitative ultrasound measurement, bipolar disorder, body fat distribution and femoral neck bone mineral density.
How long is the HROB protein?
The Homo sapiens HROB protein (UniProt Q8N3J3) is 647 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3J3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3J3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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