Protein phosphatase Mn(2+)-dependent 1K (PPM1K)
Homo sapiens — UniProt Q8N3J5
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase Mn(2+)-dependent 1K (PPM1K) is a protein from Homo sapiens identified by UniProt accession Q8N3J5, 372 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.
- UniProt accession: Q8N3J5; gene symbol PPM1K.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): maple syrup urine disease, serum metabolite measurement and blood metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase Mn(2+)-dependent 1K |
|---|---|
| UniProt accession | Q8N3J5 |
| Gene | PPM1K |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (132)
Diseases linked to this target (Open Targets).
- maple syrup urine disease · score 0.46
- serum metabolite measurement · score 0.42
- blood metabolite measurement · score 0.38
- intermediate maple syrup urine disease · score 0.37
- amino acid measurement · score 0.37
- protein measurement · score 0.28
- gout · score 0.23
- waist circumference · score 0.21
- metabolite measurement · score 0.20
- coronary artery calcification · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3J5-F1 | alphafold | PREDICTED | 83.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3J5.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPM1K?
The strongest Open Targets associations for PPM1K are maple syrup urine disease, serum metabolite measurement, blood metabolite measurement, intermediate maple syrup urine disease and amino acid measurement.
How long is the PPM1K protein?
The Homo sapiens PPM1K protein (UniProt Q8N3J5) is 372 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3J5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3J5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.