T-cell activation inhibitor, mitochondrial (TCAIM)
Homo sapiens — UniProt Q8N3R3
Data last refreshed: (UniProt release unknown)
Key facts
T-cell activation inhibitor, mitochondrial (TCAIM) is a protein from Homo sapiens identified by UniProt accession Q8N3R3, 496 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q8N3R3; gene symbol TCAIM.
- Organism: Homo sapiens.
- Length: 496 amino acids.
- Top disease associations (Open Targets): body mass index, daytime rest measurement and depressive symptom measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | T-cell activation inhibitor, mitochondrial |
|---|---|
| UniProt accession | Q8N3R3 |
| Gene | TCAIM |
| Organism | Homo sapiens |
| Length | 496 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- body mass index · score 0.30
- daytime rest measurement · score 0.22
- depressive symptom measurement · score 0.21
- unipolar depression · score 0.18
- autism spectrum disorder · score 0.13
- obsessive-compulsive disorder · score 0.13
- Tourette syndrome · score 0.13
- attention deficit hyperactivity disorder · score 0.13
- bipolar disorder · score 0.13
- schizophrenia · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3R3-F1 | alphafold | PREDICTED | 79.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3R3.
Amino-acid sequence (496 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TCAIM?
The strongest Open Targets associations for TCAIM are body mass index, daytime rest measurement, depressive symptom measurement, unipolar depression and autism spectrum disorder.
How long is the TCAIM protein?
The Homo sapiens TCAIM protein (UniProt Q8N3R3) is 496 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3R3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3R3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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