Protein PALS1 (PALS1)
Homo sapiens — UniProt Q8N3R9
Data last refreshed: (UniProt release unknown)
Key facts
Protein PALS1 (PALS1) is a protein from Homo sapiens identified by UniProt accession Q8N3R9, 675 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q8N3R9; gene symbol PALS1.
- Organism: Homo sapiens.
- Length: 675 amino acids.
- Top disease associations (Open Targets): COVID-19, severe acute respiratory syndrome and complex neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein PALS1 |
|---|---|
| UniProt accession | Q8N3R9 |
| Gene | PALS1 |
| Organism | Homo sapiens |
| Length | 675 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- complex neurodevelopmental disorder · score 0.37
- anxiety · score 0.34
- Intellectual disability · score 0.34
- cerebral palsy · score 0.34
- Abnormal facial shape · score 0.34
- arachnoid cyst · score 0.34
- reticulocyte count · score 0.14
- atypical Rett syndrome · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3R9-F1 | alphafold | PREDICTED | 77.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3R9.
Amino-acid sequence (675 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PALS1?
The strongest Open Targets associations for PALS1 are COVID-19, severe acute respiratory syndrome, complex neurodevelopmental disorder, anxiety and Intellectual disability.
How long is the PALS1 protein?
The Homo sapiens PALS1 protein (UniProt Q8N3R9) is 675 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3R9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3R9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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