Cohesin subunit SA-2 (STAG2)
Homo sapiens — UniProt Q8N3U4
Data last refreshed: (UniProt release unknown)
Key facts
Cohesin subunit SA-2 (STAG2) is a protein from Homo sapiens identified by UniProt accession Q8N3U4, 1231 residues long. MolForge cross-references it against 0 known binders and 300 disease associations.
- UniProt accession: Q8N3U4; gene symbol STAG2.
- Organism: Homo sapiens.
- Length: 1231 amino acids.
- Top disease associations (Open Targets): Mullegama-Klein-Martinez syndrome, alobar holoprosencephaly and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cohesin subunit SA-2 |
|---|---|
| UniProt accession | Q8N3U4 |
| Gene | STAG2 |
| Organism | Homo sapiens |
| Length | 1231 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (300)
Diseases linked to this target (Open Targets).
- Mullegama-Klein-Martinez syndrome · score 0.70
- alobar holoprosencephaly · score 0.66
- neurodegenerative disease · score 0.54
- urinary bladder cancer · score 0.52
- Ewing sarcoma · score 0.52
- acute myeloid leukemia · score 0.47
- genetic disorder · score 0.44
- glioblastoma multiforme · score 0.43
- urinary bladder carcinoma · score 0.39
- Microcephaly · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3U4-F1 | alphafold | PREDICTED | 79.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3U4.
Amino-acid sequence (1231 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with STAG2?
The strongest Open Targets associations for STAG2 are Mullegama-Klein-Martinez syndrome, alobar holoprosencephaly, neurodegenerative disease, urinary bladder cancer and Ewing sarcoma.
How long is the STAG2 protein?
The Homo sapiens STAG2 protein (UniProt Q8N3U4) is 1231 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3U4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3U4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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