Ligand-dependent nuclear receptor corepressor-like protein (LCORL)
Homo sapiens — UniProt Q8N3X6
Data last refreshed: (UniProt release unknown)
Key facts
Ligand-dependent nuclear receptor corepressor-like protein (LCORL) is a protein from Homo sapiens identified by UniProt accession Q8N3X6, 602 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.
- UniProt accession: Q8N3X6; gene symbol LCORL.
- Organism: Homo sapiens.
- Length: 602 amino acids.
- Target class: Nuclear receptor.
- Top disease associations (Open Targets): body height, lean body mass and sitting height measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ligand-dependent nuclear receptor corepressor-like protein |
|---|---|
| UniProt accession | Q8N3X6 |
| Gene | LCORL |
| Organism | Homo sapiens |
| Length | 602 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Nuclear receptor (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (136)
Diseases linked to this target (Open Targets).
- body height · score 0.70
- lean body mass · score 0.67
- sitting height measurement · score 0.67
- forced expiratory volume · score 0.65
- whole body water mass · score 0.61
- base metabolic rate measurement · score 0.54
- body weights and measures · score 0.53
- body mass index · score 0.48
- appendicular lean mass · score 0.47
- systolic blood pressure · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3X6-F1 | alphafold | PREDICTED | 58.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3X6.
Amino-acid sequence (602 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LCORL?
The strongest Open Targets associations for LCORL are body height, lean body mass, sitting height measurement, forced expiratory volume and whole body water mass.
How long is the LCORL protein?
The Homo sapiens LCORL protein (UniProt Q8N3X6) is 602 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3X6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3X6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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