F-box/WD repeat-containing protein 8 (FBXW8)
Homo sapiens — UniProt Q8N3Y1
Data last refreshed: (UniProt release unknown)
Key facts
F-box/WD repeat-containing protein 8 (FBXW8) is a protein from Homo sapiens identified by UniProt accession Q8N3Y1, 598 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8N3Y1; gene symbol FBXW8.
- Organism: Homo sapiens.
- Length: 598 amino acids.
- Top disease associations (Open Targets): protein measurement, body height and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/WD repeat-containing protein 8 |
|---|---|
| UniProt accession | Q8N3Y1 |
| Gene | FBXW8 |
| Organism | Homo sapiens |
| Length | 598 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.36
- body height · score 0.34
- appendicular lean mass · score 0.30
- vital capacity · score 0.29
- fat body mass · score 0.27
- lean body mass · score 0.27
- sitting height measurement · score 0.23
- whole body water mass · score 0.23
- rheumatoid arthritis · score 0.23
- marginal zone B-cell lymphoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3Y1-F1 | alphafold | PREDICTED | 76.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3Y1.
Amino-acid sequence (598 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXW8?
The strongest Open Targets associations for FBXW8 are protein measurement, body height, appendicular lean mass, vital capacity and fat body mass.
How long is the FBXW8 protein?
The Homo sapiens FBXW8 protein (UniProt Q8N3Y1) is 598 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3Y1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3Y1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.