Xylosyl- and glucuronyltransferase LARGE2 (LARGE2)
Homo sapiens — UniProt Q8N3Y3
Data last refreshed: (UniProt release unknown)
Key facts
Xylosyl- and glucuronyltransferase LARGE2 (LARGE2) is a protein from Homo sapiens identified by UniProt accession Q8N3Y3, 721 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q8N3Y3; gene symbol LARGE2.
- Organism: Homo sapiens.
- Length: 721 amino acids.
- Top disease associations (Open Targets): body height, cortical surface area measurement and risk-taking behaviour.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Xylosyl- and glucuronyltransferase LARGE2 |
|---|---|
| UniProt accession | Q8N3Y3 |
| Gene | LARGE2 |
| Organism | Homo sapiens |
| Length | 721 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- body height · score 0.31
- cortical surface area measurement · score 0.12
- risk-taking behaviour · score 0.12
- SAPHO syndrome · score 0.10
- brain measurement · score 0.09
- age-related macular degeneration · score 0.08
- antisocial behaviour measurement · score 0.08
- attention deficit hyperactivity disorder · score 0.08
- substance abuse · score 0.08
- smoking status measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3Y3-F1 | alphafold | PREDICTED | 87.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3Y3.
Amino-acid sequence (721 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LARGE2?
The strongest Open Targets associations for LARGE2 are body height, cortical surface area measurement, risk-taking behaviour, SAPHO syndrome and brain measurement.
How long is the LARGE2 protein?
The Homo sapiens LARGE2 protein (UniProt Q8N3Y3) is 721 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3Y3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3Y3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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