Epidermal retinol dehydrogenase 2 (SDR16C5)
Homo sapiens — UniProt Q8N3Y7
Data last refreshed: (UniProt release unknown)
Key facts
Epidermal retinol dehydrogenase 2 (SDR16C5) is a protein from Homo sapiens identified by UniProt accession Q8N3Y7, 309 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q8N3Y7; gene symbol SDR16C5.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Top disease associations (Open Targets): body height, cortical surface area measurement and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epidermal retinol dehydrogenase 2 |
|---|---|
| UniProt accession | Q8N3Y7 |
| Gene | SDR16C5 |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- body height · score 0.38
- cortical surface area measurement · score 0.32
- appendicular lean mass · score 0.29
- brain measurement · score 0.26
- anthropometric measurement · score 0.24
- heel bone mineral density · score 0.24
- cortical thickness · score 0.19
- whole body water mass · score 0.17
- sitting height measurement · score 0.17
- base metabolic rate measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3Y7-F1 | alphafold | PREDICTED | 94.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3Y7.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SDR16C5?
The strongest Open Targets associations for SDR16C5 are body height, cortical surface area measurement, appendicular lean mass, brain measurement and anthropometric measurement.
How long is the SDR16C5 protein?
The Homo sapiens SDR16C5 protein (UniProt Q8N3Y7) is 309 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3Y7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3Y7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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