GTP-binding protein 8 (GTPBP8)
Homo sapiens — UniProt Q8N3Z3
Data last refreshed: (UniProt release unknown)
Key facts
GTP-binding protein 8 (GTPBP8) is a protein from Homo sapiens identified by UniProt accession Q8N3Z3, 284 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q8N3Z3; gene symbol GTPBP8.
- Organism: Homo sapiens.
- Length: 284 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body height and BMI-adjusted waist circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GTP-binding protein 8 |
|---|---|
| UniProt accession | Q8N3Z3 |
| Gene | GTPBP8 |
| Organism | Homo sapiens |
| Length | 284 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- body height · score 0.12
- BMI-adjusted waist circumference · score 0.09
- protein measurement · score 0.08
- PHF-tau measurement · score 0.04
- lymphocyte count · score 0.04
- appendicular lean mass · score 0.04
- blood protein measurement · score 0.02
- breast cancer · score 0.01
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N3Z3-F1 | alphafold | PREDICTED | 84.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N3Z3.
Amino-acid sequence (284 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTPBP8?
The strongest Open Targets associations for GTPBP8 are neurodegenerative disease, body height, BMI-adjusted waist circumference, protein measurement and PHF-tau measurement.
How long is the GTPBP8 protein?
The Homo sapiens GTPBP8 protein (UniProt Q8N3Z3) is 284 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N3Z3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N3Z3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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