Misshapen-like kinase 1 (MINK1)
Homo sapiens — UniProt Q8N4C8
Data last refreshed: (UniProt release unknown)
Key facts
Misshapen-like kinase 1 (MINK1) is a protein from Homo sapiens identified by UniProt accession Q8N4C8, 1332 residues long. MolForge cross-references it against 14 known binders and 157 disease associations.
- UniProt accession: Q8N4C8; gene symbol MINK1.
- Organism: Homo sapiens.
- Length: 1332 amino acids.
- Top disease associations (Open Targets): Alzheimer disease, multiple sclerosis and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Misshapen-like kinase 1 |
|---|---|
| UniProt accession | Q8N4C8 |
| Gene | MINK1 |
| Organism | Homo sapiens |
| Length | 1332 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (157)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.33
- multiple sclerosis · score 0.32
- neurodegenerative disease · score 0.32
- Parkinson disease · score 0.32
- lysosomal storage disease · score 0.32
- lymphocyte count · score 0.28
- lymphocyte percentage of leukocytes · score 0.25
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.23
- ovarian cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N4C8-F1 | alphafold | PREDICTED | 63.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N4C8.
Amino-acid sequence (1332 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MINK1?
The strongest Open Targets associations for MINK1 are Alzheimer disease, multiple sclerosis, neurodegenerative disease, Parkinson disease and lysosomal storage disease.
How long is the MINK1 protein?
The Homo sapiens MINK1 protein (UniProt Q8N4C8) is 1332 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N4C8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N4C8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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